GDCT (Glymphatic Dynamics & Clearance Therapy) is a non-invasive, closed-loop stimulation platform built around Transcranial RF Pulse Modulation (tRFPM), combined with real-time bio-impedance feedback and our own algorithm, BAIS. Rather than directly clearing waste the way an antibody or drug would, it focuses on opening the brain's own clearance pathways — the glymphatic system, cerebrospinal fluid outflow, and the meningeal lymphatic vessels.
The glymphatic system, the brain's waste-clearance pathway, is known to be most active during sleep. We're experimentally exploring whether this flow can also be induced while awake.
Rather than a single fixed frequency, we're studying phase-response patterns tuned to an individual's neurovascular rhythm, aiming to induce sleep-specific K-complex-like slow waves in real time while awake.
Scalp and tissue impedance is measured in real time and fed into a closed loop that automatically adjusts stimulation intensity, with exposure limits enforced at the hardware level.
Our own algorithm integrates EEG, transcranial Doppler (TCD), and heart-rate variability (HRV) into a patient-level digital twin, used to titrate stimulation and interpret responses.
These are conditions in which impaired glymphatic and cerebrospinal fluid circulation is believed to play a role in pathophysiology. None of these are confirmed indications; we plan to evaluate applicability through future clinical research, one step at a time.